Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn

Seminar

Speaker: Henrik Flyvbjerg , Department of Micro- and Nanotechnology, Technical University of Denmark, Copenhagen

Title: Thermophoretic forces on DNA measured with a single-molecule spring balance. Oder: Tauziehen mit Erbgut * Colloquium on Complex and Biological Systems

Time: Fri, Feb 17, 2017, 10:15am

Place: bldg 28, room 2.011

Abstract:
We stretch a single DNA molecule with thermophoretic forces and measure these forces with a spring balance: the DNA molecule itself. It is an entropic spring which we calibrate, using as a benchmark its Brownian motion in the nanochannel that contains and prestretches it. We find the Soret coefficient per unit length of DNA at various ionic strengths [1]. It agrees, with novel precision, with results obtained in bulk for DNA too short to shield itself and with the thermodynamic model of thermophoresis. If time permits, I will briefly describe two other applications of statistical mechanics to Mbp DNA-molecules in microfluidic environments, one for optical reading of their sequence [2], another for concentrating molecules [3].

[1] J. N. Pedersen, C. J. Lüscher, R. Marie, L. H. Thamdrup, A. Kristensen, and H. Flyvbjerg. Thermophoretic forces on DNA measured with a single-molecule spring balance Phys. Rev. Lett. 113, 268301 (2014) (5 pages); doi:10.1103/PhysRevLett.113.268301

[2] J. N. Pedersen, R. Marie, A. Kristensen, and H. Flyvbjerg. How to determine local stretching and tension in a flow-stretched DNA molecule Phys. Rev. E, 93, 042405 (2016) (17 pages); doi:10.1103/PhysRevE.93.042405

[3] Y. Chen, E. S. Abrams, T. C. Boles, J. N. Pedersen, H. Flyvbjerg, R. H. Austin, and J. C. Sturm. Concentrating Genomic Length DNA in a Microfabricated Array Phys. Rev. Lett. 114, 198303 (2015) (5 pages); doi:10.1103/PhysRevLett.114.198303

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT uni-potsdam.de

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag


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