Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn


Speaker: Henrik Flyvbjerg , Department of Micro- and Nanotechnology, Technical University of Denmark, Copenhagen

Title: Thermophoretic forces on DNA measured with a single-molecule spring balance. Oder: Tauziehen mit Erbgut * Colloquium on Complex and Biological Systems

Time: Fri, Feb 17, 2017, 10:15am

Place: bldg 28, room 2.011

We stretch a single DNA molecule with thermophoretic forces and measure these forces with a spring balance: the DNA molecule itself. It is an entropic spring which we calibrate, using as a benchmark its Brownian motion in the nanochannel that contains and prestretches it. We find the Soret coefficient per unit length of DNA at various ionic strengths [1]. It agrees, with novel precision, with results obtained in bulk for DNA too short to shield itself and with the thermodynamic model of thermophoresis. If time permits, I will briefly describe two other applications of statistical mechanics to Mbp DNA-molecules in microfluidic environments, one for optical reading of their sequence [2], another for concentrating molecules [3].

[1] J. N. Pedersen, C. J. Lüscher, R. Marie, L. H. Thamdrup, A. Kristensen, and H. Flyvbjerg. Thermophoretic forces on DNA measured with a single-molecule spring balance Phys. Rev. Lett. 113, 268301 (2014) (5 pages); doi:10.1103/PhysRevLett.113.268301

[2] J. N. Pedersen, R. Marie, A. Kristensen, and H. Flyvbjerg. How to determine local stretching and tension in a flow-stretched DNA molecule Phys. Rev. E, 93, 042405 (2016) (17 pages); doi:10.1103/PhysRevE.93.042405

[3] Y. Chen, E. S. Abrams, T. C. Boles, J. N. Pedersen, H. Flyvbjerg, R. H. Austin, and J. C. Sturm. Concentrating Genomic Length DNA in a Microfabricated Array Phys. Rev. Lett. 114, 198303 (2015) (5 pages); doi:10.1103/PhysRevLett.114.198303

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Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
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