Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn

Seminar

Speaker: Ludivine Frontona, Institute of Biochemistry, University of Potsdam and Graduate Research Training Program PharMetrX: Pharmacometrics & Computational Disease Modeling, Free University Berlin and University of Potsdam

Title: Benefits of mechanism-based modeling to characterize the pharmacokinetic properties of therapeutic monoclonal antibodies * Bioinformatics Affinity Seminar

Time: Wed, Apr 3, 2013, 10am

Place: MPI für Molekulare Pflanzenphysiologie, Room 0.21 in The Box

Abstract:
Therapeutic monoclonal antibodies (mAbs) are mainly engineered immunoglobulins type G (IgG) which are proteins directed against a specific target. They are essential assets in the treatment of cancer, inflammatory and infectious diseases. It is important to understand their pharmacokinetic properties, i.e. absorption, distribution, metabolism and excretion (ADME) in order to recommend safe and efficacious dosing regimens. These properties are commonly characterized with an empiric compartmental approach applied to the plasma data. However, there is a high interest in developing predictive mechanistic pharmacokinetic models describing the detailed knowledge of the molecular processes involved in the ADME of mAbs. Physiologically-based pharmacokinetic (PBPK) models represent a primary choice because they allow integrating physiological data (e.g. plasma and lymph flows, plasma and tissue volumes) and in vivo data (e.g. plasma and tissue concentrations). So far, existing PBPK models developed in mice are not satisfactory because they either do not take into account the impact of endogenous immunoglobulins type G or tissue data for model building. We developed a PBPK model for mAbs, in mice, in the absence of target which accounts for plasma and tissue data and the most relevant mechanism governing their ADME properties. We applied model reduction techniques in order to derive a physiology-based-low-dimensional model and draw a parallel with the empirical approach. This is joint work with Prof. Wilhelm Huisinga.

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT uni-potsdam.de

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag


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