Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn

Seminar

Speaker: Macus J. B. Hauser, Institut für Experimentelle Physik, Abteilung Biophysik, Otto-von-Guericke-Universität Magdeburg

Title: Cell-cell desynchronisation in yeast cell populations * Colloquium on Complex and Biological Systems

Time: Fri, Feb 1, 2013, 10:15am

Place: bldg 28, room 0.108

Abstract:
Colonies of the yeasts Saccharomyces carlsbergensis and Saccharomyces cerevisiae have been used as stable model organisms to investigate glycolytic oscillations. Thus, the yeast population can be considered as a series of coupled oscillators. The dynamics of the cell population depend on the cell density: At high cell densities all cells of the population show synchronous and coherent oscillations, which can be detected as global oscillations. The collective behaviour ceases at a critical, low cell density, but the nature of the dynamics at single cell level remained an open question. Recent reports predicted an 'amplitude death' mechanism, where all cells stop oscillating synchronously below the quorum (i.e. the critical cell density).

Using single photon counting fluorescence microscopy, we study the dynamics of individual yeast cells at low cell densities for both yeast strains. Our focus lies in elucidating the mechanism of the transition between individual and collective dynamics. At very low cell densities, the individual cells still perform metabolic oscillations, the frequencies of which show a very broad distribution. Thus the cells oscillate in a desynchronous fashion. As the cell density increases, we observe that the frequency distribution narrows and synchronized collective behaviour sets in. We show that the transition from desynchronized to synchronized behaviour follows a Kuramoto transition, and therefore we can preclude an 'amplitude death' phenomenon (as predicted by former work) to tale place in glycolytic oscillations if the yeast strains S. carlsbergensis and S. cerevisiae.

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT uni-potsdam.de

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag


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