Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn

Seminar

Speaker: Dorothea Hemme, Timo Mühlhaus, Julia Weiß, Georg Basler, University of Potsdam and Max Planck Institute of Molecular Plant Physiology

Title: The GoFORSYS project - Systems biology from the fermenter to databases and beyond

Time: Wed, Mar 3, 2010, 1:15pm

Place: Building 28, Room 0.108 (ground floor)

Abstract:
GoFORSYS is a Systems Biology project to analyze photosynthesis and its regulation in response to selected environmental factors using the eukaryotic green alga Chlamydomonas reinhardtii as major model organism (www.GoFORSYS.de). This project is a collaborative effort of the Institute of Biochemistry and Biology at the University of Potsdam, the Max Planck Institute of Molecular Plant Physiology and the Max Planck Institute of Colloids and Interfaces.
Chlamydomonas reinhardtii was chosen because of its unicellularity, which precludes influences by tissue heterogeneity and development, and because it can be cultivated under controlled conditions in a bioreactor. Changes in photosynthetic capability, gene expression, polysome loading, lipid composition, metabolite and protein concentrations in response to defined changes in environmental conditions are analyzed within different Core Experiments. Modelling and simulation methods for the reconstruction of cellular processes specific to the corresponding treatment and the integrated analysis of complex profile data are currently applied and developed. One example is the identification of significant topological properties of the reconstructed metabolic network using biochemically constrained network randomization.
In our talks we will describe the necessary steps from experimental to modelling issues. We will explain the setup and performance of high throughput experiments, sample preparation, data processing and data management on the basis of the proteomics part of GoFORSYS. As an example for the modelling efforts performed in GoFORSYS we will present results obtained from the randomization of genome-scale metabolic networks.

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT uni-potsdam.de

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag


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