Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn

Seminar

Speaker: Sebastian Klie, AG Bioinformatics

Title: Canonical correlation analysis of genes and metabolites in the primary metabolism of E. coli

Time: Wed, Feb 3, 2010, 10:00am

Place: MPI für Molekulare Pflanzenphysiologie, Room 0.21 in The Box

Abstract:
Canonical correlation analysis (CCA) is a statistical technique for studying associations between two sets of variables measured under the same experimental units. CCA and its variants can be applied to either compare data of the same source (e.g. micro-array data) originating from different species or to integrate different sources of data from the same system (e.g. complementing gene expression data with phenotypic data or integration of data originating from different 'omics' technologies). This seminar focuses on the theoretical principles of CCA, discusses advantages as well as limitations and provides an overview of available packages for the statistical software R.

Furthermore, the application of CCA is illustrated on a joint dataset comprised of the gene expression levels and metabolite concentrations measured as a time-course experiment under 6 environmental conditions in E. coli. Specifically, we identified a number of condition dependent associations between metabolites and transcripts. The results obtained confirm and extend existing models about coregulation between gene expression and metabolites demonstrating the power of integrated systems oriented analysis.

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT uni-potsdam.de

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag


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