Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn


Speaker: Hesam Montazeri, ETH Zurich, Basel, Switzerland

Title: Waiting time model for accumulating mutations * Computational physiology group

Time: Fri, Oct 10, 2014, 11:15am

Place: bldg 25, room B 0.01

HIV drug resistance development is a consequence of viral evolution. This evolutionary process is characterized mainly by the accumulation of resistance mutations, i.e., mutations that confer a selective advantage under the selective pressure of antiviral drugs. Different statistical models including the continuous time conjunctive Bayesian network (CBN) model have been proposed for modeling the accumulation of mutations. The continuous time CBN represents a waiting time process for the accumulation of mutations where the occurrences of mutations are subject to some constraints. Consequently, according to this model, evolution follows only a subset of all possible mutational pathways from the wild type, the genotype carrying no mutation, to the fully resistant genotype, the genotype carrying all resistance mutations.
In this talk, I will present the CBN model and some recent improvements of the model in detail and as an application I will demonstrate how this model can help to improve HIV treatment outcome prediction.

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag

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