Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn


Speaker: Jost Neigenfind, AG Bioinformatics

Title: Prisoners in a cave - A critical view on flux balance analysis

Time: Wed, Jun 9, 2010, 10:00am

Place: MPI für Molekulare Pflanzenphysiologie, Room 0.21 in The Box

Predicting the metabolic state of cells after conditional changes is a challenging task, because the regulatory system undergoes a series of transient metabolic changes that converge to a new steady-state condition. Flux balance analysis (FBA) is often used for simulation and prediction in metabolic networks because of its high performance. Nevertheless, if the outcomes of FBA and FBA related methods are analyzed in detail the results seem arbitrary and can be manipulated easily. The usefulness of FBA besides the calculation of a simple objective function is evaluated by applying a modified FBA related method on different metabolic phenotypes of Synechocystis. FBA is able to make useful predictions under well defined assumptions, but fails if such assumptions can not be made.

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag

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