Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn

Seminar

Speaker: Lene Oddershede, Niels Bohr Institut, Denmark

Title: Dynamics of cells and within cells * Colloquium on Complex and Biological Systems

Time: Fri, Oct 23, 2015, 10:15am

Place: bldg 28, room 0.108

Abstract:
Cells making up biological tissue are connected and their motility highly correlated. The focus of this talk is on a physical description of the complex dynamics of and within cells comprising different tissue types. Endothelial cells line the blood vessels. In healthy vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Under non-flow conditions, mimicking the condition around a blood clot, we show that a cell division in endothelial tissue causes the emergence of long-range well-ordered vortex patterns, in spite of the system’s low Reynolds number [1]. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase. We also experimentally mimic the conditions of a closing wound and investigate how endothelial cells migrate into empty space, and how this migration depends on flow conditions. Another system studied is cancerous tissue, here, we correlate the aggressiveness of cancer cells to their dynamics, with the goal of achieving a deeper understanding of how dynamics is related to cancer invasiveness. The last part of the talk focuses on the dynamics of organelles inside living stem cells, and how these tracers can be used as a mean to characterize the mechanical properties of stem cells; we found that the mechanical properties of embryonic stem cells is highly correlated to their differentiation and that the presence of actin might serve as a check-point for differentiation control.

[1] Rossen, Tarp, Mathiesen, Jensen, Oddershede, Nature Communications vol 5 p. 5720 (2014)

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT uni-potsdam.de

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag


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