Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn


Speaker: Rainer Klages, School of Mathematical Sciences, Queen Mary, University of London, UK

Title: Anomalous dynamics of cell migration

Time: Mon, Jun 7, 2010, 3:00pm

Place: Building 28, Room 2.123


Cell movement, for example, during embryogenesis or tumor metastasis, is a complex dynamical process resulting from an intricate interplay of multiple components of the cellular migration machinery. At first sight, the paths of migrating cells resemble those of thermally driven Brownian particles. However, cell migration is an active biological process putting a characterization in terms of normal Brownian motion into question.

By analyzing the trajectories of both wild-type and mutated epithelial (transformed Madin-Darby canine kidney) kidney cells, we show experimentally that anomalous dynamics [1] characterizes cell migration. A superdiffusive increase of the mean square displacement, non-Gaussian spatial probability distributions and power-law decays of the velocity autocorrelations are the basis for this interpretation.

Almost all results can be explained with a fractional Klein-Kramers equation allowing the quantitative classification of cell migration by a few parameters [2].

[1] R. Klages, G.Radons, I.M.Sokolov (Eds.), Anomalous transport (Wiley-VCH, Weinheim, 2008)

[2] P.Dieterich, R.Klages, R.Preuss, A.Schwab, PNAS 105, 459 (2008)

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
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DFG Sonderforschungsbereich 1294 Data assimilation

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