Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn


Speaker: Arik Yochelis, Ben-Gurion University, Israel

Title: Pattern formation approach to dynamical properties of Filopodia * Joint Event: Colloquium on Complex and Biological Systems / Seminar of the GRK 1558

Time: Fri, June 21, 2013, 10:15am

Place: bldg 28, room 0.108

Filopodia are cellular protrusions and are paramount to cell functionalities, examples of which include cell migration, neurite outgrowth, and wound healing (sensing). Therefore, understanding the filopodia properties is not only an important task but also highly challenging intellectually due to their diverse spatiotemporal behaviors. In my talk I will focus on two topics, both approached by the pattern formation theory:

- Filopodia initiation: Traditionally cellular models do not include feedback between cellular shape changes and biochemical reactions. Here we introduce a novel reaction-diffusion-elasticity approach towards understanding the key ingredients of Filopodia initiation: the reaction-diffusion part describes bistability between two actin orientations and couples to the elastic energy of the cell membrane deformations. It is found that an addition of such coupling generates localized patterns which are not possible otherwise. We apply this concept to describe the initiation of actin-based protrusions, and compare with experimental observations.

- Transport in Filopodia: Self-organization of myosin motors into propagating aggregates along the Filopodia is a prominent problem. Although individual motors move in opposite directions, the aggregates move mostly either in a periodic structure or in a spatially localized fashion, apparently being generated at the filopodia tip. From a biological point of view, temporal variations at the protrusion tip are speculated to have an intimate interrelationship between the protrusion elongation and the myosin transport. Here we link through a novel conserved-reaction-diffusion-advection model, between the mass/flux conservation and the boundary conditions to resolve the pattern selection mechanisms that give rise to either traveling waves or excitable pulses. In turn, the latter provide insights into the dynamical control (depletion) of myosins in the tip region.

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT

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