Seminars of the Focus Area Complex Systems

Prof. Dr. C. Beta, Prof. Dr. K. Dethloff, Prof. Dr. R. Engbert, Prof. Dr. M. Holschneider, Prof. Dr. W. Huisinga, Prof. Dr. Ralf Metzler, Prof. Dr. A. Pikovsky, Prof. Dr. S. Reich, Prof. Dr. M. Rosenblum, Prof. Dr. G. Rüdiger, Prof. Dr. T. Scheffer, Prof. Dr. F. Scherbaum, Prof. Dr. J. Selbig, Prof. Dr. F. Spahn

Seminar

Speaker: Bert de Groot, Max-Planck-Institute für Biophysikalische Chemie, Göttingen

Title: The molecular dynamics and energetics of ion permeation and molecular recognition * Colloquium on Complex and Biological Systems

Time: Fri, June 24, 2016, 10:15am

Place: bldg 28, room 0.108

Abstract:
Which are the mechanisms underlying molecular recognition involved in protein complexes? How do K+ ions efficiently, yet selectively pass through potassium channels? How can designed conformational shifts control binding affinity or selectivity? Molecular dynamics simulation results will be presented to address these questions. Ubiquitin data will be presented that suggest a conformational selection mechanism that allow it to engage in a large number of different complexes, each requiring a specific conformation. Indeed, designed mutants in the ubiquitin core with an altered conformational equilibrium show a corresponding shift in binding specificity. In addition, results from computational electrophysiology simulations will be shown that show the efficient permeation of K+ ions, but not of the slightly smaller Na+ ions through the selectivity filter of potassium channels.

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Past NLD Seminars (1994-2007) & (2008 ...)

Students' seminar: Theoretical Physics, PIK, Modeling & TSA Berlin-Potsdam-Colloquia: PhysGesellschaft Berlin, TU Berlin, Pro Physik, AIP, AEI, MPI-KGF, GFZ, HMI, PIK, AWI, Max Planck Institute for the History of Science, Mathematik, DPG Disputationen, & Vorschau UP

Udo Schwarz, Zentrum für Dynamik komplexer Systeme,
Universität Potsdam, Campus Golm Karl-Liebknecht-Str. 24, 14476 Potsdam, building 28, room 2.107
Phone: (+49-331) 977-1658, Fax : (+49-331) 977-1045

Email: Udo.Schwarz AT uni-potsdam.de

DFG SFB 1294

DFG Sonderforschungsbereich 1294 Data assimilation

DFG SPP 1488

DFG Schwerpunktprogramm 1488 Planetmag


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